- Abberger, Claire (x)
- Chandler, Morgan (x)
- Search results
Search results
- Title
- Artificial immune cell, AI-cell, a new tool to predict interferon production by peripheral blood monocytes in response to nucleic acid nanoparticles
- Author
- Afonin, Kirill A., Chandler, Morgan, Halman, Justin
- Date Created
- 2022
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Nucleic acid nanoparticles, or NANPs, rationally designed to communicate with the human immune system, can offer innovative therapeutic strategies to overcome the limitations of traditional nucleic acid therapies. Each set of NANPs is unique in th...
- Title
- Broccoli fluorets : split aptamers as a user-friendly fluorescent toolkit for dynamic RNA nanotechnology
- Author
- Afonin, Kirill A., Chandler, Morgan, Halman, Justin
- Date Created
- 2018
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- RNA aptamers selected to bind fluorophores and activate their fluorescence offer a simple and modular way to visualize native RNAs in cells. Split aptamers which are inactive until the halves are brought within close proximity can become useful fo...
- Title
- DNA-templated fluorescent silver nanoclusters inhibit bacterial growth while being non-toxic to mammalian cells
- Author
- Afonin, Kirill A., Chandler, Morgan, Rolband, Lewis
- Date Created
- 2021
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Silver has a long history of antibacterial effectiveness. The combination of atomically precise metal nanoclusters with the field of nucleic acid nanotechnology has given rise to DNA-templated silver nanoclusters (DNA-AgNCs) which can be engineere...
- Title
- Dynamic and Conditionally Activated Nucleic Acid Nanoparticles
- Author
- Chandler, Morgan
- Date Created
- 2021
- Subjects--Topical
- Nanoscience
- Description
- Programmed interactions of nucleic acids—including DNA and RNA—orchestrate genetic expression and downstream cellular processes at every level. The structures of nucleic acids rely on their sequences, which include traditional Watson-Crick base pa...
- Title
- Expanding structural space for immunomodulatory nucleic acid nanoparticles (NANPs) via spatial arrangement of their therapeutic moieties
- Author
- Afonin, Kirill A., Chandler, Morgan, Rolband, Lewis
- Date Created
- 2022
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Different therapeutic nucleic acids (TNAs) can be unified in a single structure by their elongation with short oligonucleotides designed to self-assemble into nucleic acid nanoparticles (NANPs). With this approach, therapeutic cocktails with preci...
- Title
- Functionally-interdependent shape-switching nanoparticles with controllable properties
- Author
- Halman, Justin, Khisamutdinov, Emil F., Afonin, Kirill A., Satterwhite, Emily, Roark, Brandon, Chandler, Morgan, Ivanina, Anna, Viard, Mathias, Bindewald, Eckart, Kasprzak, Wojciech K., Panigaj, Martin, Bui, My N., Lu, Jacob S., Miller, Johann, Shapiro, Bruce A., Dobrovolskaia, Marina A.
- Subjects--Topical
- Nucleic acids, Nanotechnology
- Description
- We introduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully complementary and functionally-interdependent to each other. In the described approach, the physical interaction between sets of designed nanoparticles ini...
- Title
- Functionally-interdependent shape-switching nanoparticles with controllable properties
- Author
- Afonin, Kirill A., Halman, Justin, Chandler, Morgan
- Date Created
- 2017
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- We introduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully complementary and functionally-interdependent to each other. In the described approach, the physical interaction between sets of designed nanoparticles ini...
- Title
- Induction of cytokines by nucleic acid nanoparticles (NANPs) depends on the type of delivery carrier
- Author
- Afonin, Kirill A., Chandler, Morgan, Avila, Yelixza I.
- Date Created
- 2021
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these ...
- Title
- Smart-responsive nucleic acid nanoparticles (NANPs) with the potential to modulate immune behavior
- Author
- Afonin, Kirill A., Chandler, Morgan
- Date Created
- 2019
- Subjects--Topical
- Nucleic acids, Chemistry
- Description
- Nucleic acids are programmable and biocompatible polymers that have beneficial uses in nanotechnology with broad applications in biosensing and therapeutics. In some cases, however, the development of the latter has been impeded by the unknown imm...