Search results | J. Murrey Atkins Library

Title: GSI treatment preserves protein synthesis in C2C12 myotubes
Author: Arthur, Susan, Huot, Joshua, Marino, Joseph S., Thompson, Brian, McMullen, Charlotte
Subjects--Topical: Muscle proteins, Cells
Description: It has been demonstrated that inhibiting Notch signaling through γ-secretase inhibitor (GSI) treatment increases myogenesis, AKT/mTOR signaling, and muscle protein synthesis (MPS) in C2C12 myotubes. The purpose of this study was to determine if GS...

Title: High fat rodent models of type 2 diabetes : from rodent to human
Author: Stott Bond, Nicole L., Marino, Joseph S.
Subjects--Topical: Non-insulin-dependent diabetes, Metabolism
Description: Poor dietary habits contribute to increased incidences of obesity and related co-morbidities, such as type 2 diabetes (T2D). The biological, genetic, and pathological implications of T2D, are commonly investigated using animal models induced by a ...

Title: Notch inhibition via GSI treatment elevates protein synthesis in C2C12 myotubes
Author: Arthur, Susan, Huot, Joshua, Marino, Joseph S., Turner, Michael
Subjects--Topical: Proteins--Synthesis, Muscle proteins
Description: The role of Notch signaling is widely studied in skeletal muscle regeneration but little is known about its influences on muscle protein synthesis (MPS). The purpose of this study was to investigate whether Notch signaling is involved in the regul...

Title: The association of COPD exacerbations with new onset type 2 diabetes among Medicare patients
Author: Marino, Joseph S., Ruban, Cynthiya, Saunders, Bill, Blanchette, Christopher M.
Subjects--Topical: Lungs--Diseases, Obstructive, Non-insulin-dependent diabetes
Description: Objective: Chronic obstructive pulmonary disease (COPD) is highly prevalent in the elderly population and typically reduces overall quality of life. Exacerbations of COPD are commonly treated with corticosteroids, a class of drug known to cause in...