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Artificial immune cell, AI-cell, a new tool to predict interferon production by peripheral blood monocytes in response to nucleic acid nanoparticles
Title
Artificial immune cell, AI-cell, a new tool to predict interferon production by peripheral blood monocytes in response to nucleic acid nanoparticles
Author
Afonin, Kirill A., Chandler, Morgan, Halman, Justin
Date Created
2022
Subjects--Topical
Nucleic acids, Chemistry
Description
Nucleic acid nanoparticles, or NANPs, rationally designed to communicate with the human immune system, can offer innovative therapeutic strategies to overcome the limitations of traditional nucleic acid therapies. Each set of NANPs is unique in th...
Break to build : isothermal assembly of nucleic acid nanoparticles (NANPs) via enzymatic degradation
Title
Break to build : isothermal assembly of nucleic acid nanoparticles (NANPs) via enzymatic degradation
Author
Beasock, Damian, Ha, Anh, Halman, Justin, Afonin, Kirill A.
Date Created
2023
Subjects--Topical
Genetics, Peptides
Description
The intrinsic properties of RNA and DNA biopolymers emphasized by engineered nucleic acid nanoparticles (NANPs) offer accelerated development of next-generation therapies. The rational design of NANPs facilitates programmable architectures intende...
Broccoli fluorets : split aptamers as a user-friendly fluorescent toolkit for dynamic RNA nanotechnology
Title
Broccoli fluorets : split aptamers as a user-friendly fluorescent toolkit for dynamic RNA nanotechnology
Author
Afonin, Kirill A., Chandler, Morgan, Halman, Justin
Date Created
2018
Subjects--Topical
Nucleic acids, Chemistry
Description
RNA aptamers selected to bind fluorophores and activate their fluorescence offer a simple and modular way to visualize native RNAs in cells. Split aptamers which are inactive until the halves are brought within close proximity can become useful fo...
Editorial for the special issue on nucleic acid architectures for therapeutics, diagnostics, devices and materials
Title
Editorial for the special issue on nucleic acid architectures for therapeutics, diagnostics, devices and materials
Author
Afonin, Kirill A., Halman, Justin
Date Created
2019
Subjects--Topical
Nucleic acids, Chemistry
Functionally-interdependent shape-switching nanoparticles with controllable properties
Title
Functionally-interdependent shape-switching nanoparticles with controllable properties
Author
Halman, Justin, Khisamutdinov, Emil F., Afonin, Kirill A., Satterwhite, Emily, Roark, Brandon, Chandler, Morgan, Ivanina, Anna, Viard, Mathias, Bindewald, Eckart, Kasprzak, Wojciech K., Panigaj, Martin, Bui, My N., Lu, Jacob S., Miller, Johann, Shapiro, Bruce A., Dobrovolskaia, Marina A.
Subjects--Topical
Nucleic acids, Nanotechnology
Description
We introduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully complementary and functionally-interdependent to each other. In the described approach, the physical interaction between sets of designed nanoparticles ini...
Functionally-interdependent shape-switching nanoparticles with controllable properties
Title
Functionally-interdependent shape-switching nanoparticles with controllable properties
Author
Afonin, Kirill A., Halman, Justin, Chandler, Morgan
Date Created
2017
Subjects--Topical
Nucleic acids, Chemistry
Description
We introduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully complementary and functionally-interdependent to each other. In the described approach, the physical interaction between sets of designed nanoparticles ini...
Immunostimulatory Properties of Nucleic Acid Nanoparticles
Title
Immunostimulatory Properties of Nucleic Acid Nanoparticles
Author
Halman, Justin
Date Created
2020
Subjects--Topical
Nanoscience
Description
Nucleic acids (DNA and RNA) are ubiquitous biomolecules found throughout all living organisms. They can act as genetic information storage and messengers, enzymes, molecular switches, and much more. Although DNA is used almost exclusively for its ...