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Notch inhibition via GSI treatment elevates protein synthesis in C2C12 myotubes
Title
Notch inhibition via GSI treatment elevates protein synthesis in C2C12 myotubes
Author
Arthur, Susan, Huot, Joshua, Marino, Joseph S., Turner, Michael
Subjects--Topical
Proteins--Synthesis, Muscle proteins
Description
The role of Notch signaling is widely studied in skeletal muscle regeneration but little is known about its influences on muscle protein synthesis (MPS). The purpose of this study was to investigate whether Notch signaling is involved in the regul...
GSI treatment preserves protein synthesis in C2C12 myotubes
Title
GSI treatment preserves protein synthesis in C2C12 myotubes
Author
Arthur, Susan, Huot, Joshua, Marino, Joseph S., Thompson, Brian, McMullen, Charlotte
Subjects--Topical
Muscle proteins, Cells
Description
It has been demonstrated that inhibiting Notch signaling through γ-secretase inhibitor (GSI) treatment increases myogenesis, AKT/mTOR signaling, and muscle protein synthesis (MPS) in C2C12 myotubes. The purpose of this study was to determine if GS...
Ajuga turkestanica increases Notch and Wnt signaling in aged skeletal muscle
Title
Ajuga turkestanica increases Notch and Wnt signaling in aged skeletal muscle
Author
Arthur, Susan, Howden, Reuben, Zwetsloot, Kevin, Shanely, Andrew
Subjects--Topical
Musculoskeletal system, Cells
Description
Abstract. – BACKGROUND: The declining myogenic potential of aged skeletal muscle is multifactorial. Insufficient satellite cell activity is one factor in this process. Notch andWnt signaling are involved in various biological processes including o...