Search results
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Title
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Functional dynamics of substrate recognition in tem beta-lactamase
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Author
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Jacobs, Donald J., Avery, Chris, Baker, Lonnie
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Date Created
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2022
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Subjects--Topical
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Machine learning, Molecular dynamics
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Description
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The beta-lactamase enzyme provides effective resistance to beta-lactam antibiotics due to substrate recognition controlled by point mutations. Recently, extended-spectrum and inhibitor-resistant mutants have become a global health problem. Here, t...
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Title
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DO DYNAMIC ALLOSTERIC EFFECTS OCCUR IN IGG4 ANTIBODIES?
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Author
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Baker, Lonnie
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Date Created
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2020
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Subjects--Topical
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Bioinformatics, Biophysics
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Description
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Antibodies are large, multi-chain proteins which play a critical roll in the func-tioning of vertebrate immune systems. Immune effector cells which are responsiblefor the destruction of foreign antigens do not randomly target molecules but rely on...
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Title
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Neural Network and Random Forest Based Eukaryotic Gene Prediction Methods
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Author
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Baker, Lonnie
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Date Created
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2023
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Subjects--Topical
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Bioinformatics
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Description
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Gene prediction, a fundamental task in genomics, plays a pivotal role in decipheringthe functional elements of genomes. However, accurate gene prediction remains a challenging endeavor, especially when dealing with non-model organisms that often l...