Search results
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Title
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Artificial immune cell, AI-cell, a new tool to predict interferon production by peripheral blood monocytes in response to nucleic acid nanoparticles
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Author
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Afonin, Kirill A., Chandler, Morgan, Halman, Justin
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Date Created
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2022
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Subjects--Topical
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Nucleic acids, Chemistry
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Description
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Nucleic acid nanoparticles, or NANPs, rationally designed to communicate with the human immune system, can offer innovative therapeutic strategies to overcome the limitations of traditional nucleic acid therapies. Each set of NANPs is unique in th...
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Title
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Characterization of cationic bolaamphiphile vesicles for sirna delivery into tumors and brain
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Author
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Afonin, Kirill A., Kim, Taejin, Gupta, Kshitij
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Date Created
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2020
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Subjects--Topical
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Nucleic acids, Chemistry
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Description
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Small interfering RNAs (siRNAs) are potential therapeutic substances due to their gene silencing capability as exemplified by the recent approval by the US Food and Drug Administration (FDA) of the first siRNA therapeutic agent (patisiran). Howeve...
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Title
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Exosome mediated delivery of functional nucleic acid nanoparticles (NANPs)
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Author
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Afonin, Kirill A., Ke, Weina
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Date Created
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2020
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Subjects--Topical
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Nucleic acids, Chemistry
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Description
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RNAi-based technologies have shown biomedical potential; however, safe and efficient delivery of RNA remains a barrier for their broader clinical applications. Nucleic acid nanoparticles (NANPs) programmed to self-assemble and organize multiple th...
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Title
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Functionally-interdependent shape-switching nanoparticles with controllable properties
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Author
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Afonin, Kirill A., Halman, Justin, Chandler, Morgan
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Date Created
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2017
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Subjects--Topical
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Nucleic acids, Chemistry
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Description
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We introduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully complementary and functionally-interdependent to each other. In the described approach, the physical interaction between sets of designed nanoparticles ini...
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Title
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The recognition of and reactions to nucleic acid nanoparticles by human immune cells
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Author
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Afonin, Kirill A., Bila, Dominika, Panigaj, Martin
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Date Created
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2021
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Subjects--Topical
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Nucleic acids, Chemistry
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Description
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The relatively straightforward methods of designing and assembling various functional nucleic acids into nanoparticles offer advantages for applications in diverse diagnostic and therapeutic approaches. However, due to the novelty of this approach...
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Title
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Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles
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Author
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Afonin, Kirill A., Marriott, Ian, Panigaj, Martin
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Date Created
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2023
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Subjects--Topical
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Nucleic acids, Chemistry
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Description
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The immune system has evolved to defend organisms against exogenous threats such as viruses, bacteria, fungi, and parasites by distinguishing between self and non-self. In addition, it guards us against other diseases, such as cancer, by detecting...