Search results
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Title
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Immunostimulatory Properties of Nucleic Acid Nanoparticles
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Author
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Halman, Justin
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Date Created
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2020
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Subjects--Topical
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Nanoscience
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Description
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Nucleic acids (DNA and RNA) are ubiquitous biomolecules found throughout all living organisms. They can act as genetic information storage and messengers, enzymes, molecular switches, and much more. Although DNA is used almost exclusively for its ...
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Title
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The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
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Author
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Johnson, M. Brittany, Halman, Justin, Marriott, Ian, Afonin, Kirill A., Miller, Daniel K., Cooper, Joseph S., Khisamutdinov, Emil F.
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Subjects--Topical
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Immunology, Nucleic acids, Nanoparticles
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Description
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Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...
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Title
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Functionally-interdependent shape-switching nanoparticles with controllable properties
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Author
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Halman, Justin, Khisamutdinov, Emil F., Afonin, Kirill A., Satterwhite, Emily, Roark, Brandon, Chandler, Morgan, Ivanina, Anna, Viard, Mathias, Bindewald, Eckart, Kasprzak, Wojciech K., Panigaj, Martin, Bui, My N., Lu, Jacob S., Miller, Johann, Shapiro, Bruce A., Dobrovolskaia, Marina A.
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Subjects--Topical
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Nucleic acids, Nanotechnology
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Description
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We introduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully complementary and functionally-interdependent to each other. In the described approach, the physical interaction between sets of designed nanoparticles ini...
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Title
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Artificial immune cell, AI-cell, a new tool to predict interferon production by peripheral blood monocytes in response to nucleic acid nanoparticles
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Author
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Afonin, Kirill A., Chandler, Morgan, Halman, Justin
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Date Created
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2022
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Subjects--Topical
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Nucleic acids, Chemistry
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Description
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Nucleic acid nanoparticles, or NANPs, rationally designed to communicate with the human immune system, can offer innovative therapeutic strategies to overcome the limitations of traditional nucleic acid therapies. Each set of NANPs is unique in th...
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Title
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Functionally-interdependent shape-switching nanoparticles with controllable properties
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Author
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Afonin, Kirill A., Halman, Justin, Chandler, Morgan
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Date Created
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2017
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Subjects--Topical
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Nucleic acids, Chemistry
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Description
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We introduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully complementary and functionally-interdependent to each other. In the described approach, the physical interaction between sets of designed nanoparticles ini...