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Genetic Structure and Gene Expression Profile of Plasmodium vivax in East Africa
Title
Genetic Structure and Gene Expression Profile of Plasmodium vivax in East Africa
Author
Kepple, Daniel
Date Created
2022
Subjects--Topical
Biology, Molecular biology, Cytology
Description
Plasmodium vivax malaria is a neglected tropical disease, despite being more geographically widespread than any other form of malaria. P. vivax was previously thought to be rare or absent in Africa because people of African descent often lack the ...
Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance
Title
Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance
Author
Janies, Daniel, Lo, Eugenia, Kepple, Daniel
Date Created
2019
Subjects--Topical
Communicable diseases, Malaria
Description
Plasmodium vivax invasion of human erythrocytes depends on the Duffy Binding Protein (PvDBP) which interacts with the Duffy antigen. PvDBP copy number has been recently shown to vary between P. vivax isolates in Sub-Saharan Africa. However, the ex...
Whole genome sequencing of Plasmodium vivax isolates reveals frequent sequence and structural polymorphisms in erythrocyte binding genes
Title
Whole genome sequencing of Plasmodium vivax isolates reveals frequent sequence and structural polymorphisms in erythrocyte binding genes
Author
Janies, Daniel, Lo, Eugenia, Ford, Anthony, Kepple, Daniel
Date Created
2020
Subjects--Topical
Communicable diseases, Malaria
Description
Plasmodium vivax malaria is much less common in Africa than the rest of the world because the parasite relies primarily on the Duffy antigen/chemokine receptor (DARC) to invade human erythrocytes, and the majority of Africans are Duffy negative. R...
Submicroscopic infection and G6PD deficiency in malaria patients
Title
Submicroscopic infection and G6PD deficiency in malaria patients
Author
Witherspoon, Logan, Witherspoon, Logan, Kepple, Daniel, Lo, Eugenia, Abagero, Beka
Date Created
2022, 2022, 2022
Subjects--Topical
Malaria, Public health
Description
Plasmodium vivax malaria is a neglected tropical disease, despite being more geographically widespread than any other form of malaria. Glucose-6-phosphate dehydrogenase (G6PD) is a cytosolic enzyme with a vital role for the integrity and functioni...