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The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Title
The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Author
Afonin, Kirill A., Marriott, Ian, Halman, Justin
Date Created
2020
Subjects--Topical
Nucleic acids, Chemistry
Description
Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...
Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells
Title
Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells
Author
Afonin, Kirill A., Marriott, Ian, Halman, Justin
Date Created
2020
Subjects--Topical
Nucleic acids, Chemistry
Description
Background Bacterial meningitis and meningoencephalitis are associated with devastating neuroinflammation. We and others have demonstrated the importance of glial cells in the initiation of immune responses to pathogens invading the central nervou...
Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles
Title
Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles
Author
Afonin, Kirill A., Marriott, Ian, Panigaj, Martin
Date Created
2023
Subjects--Topical
Nucleic acids, Chemistry
Description
The immune system has evolved to defend organisms against exogenous threats such as viruses, bacteria, fungi, and parasites by distinguishing between self and non-self. In addition, it guards us against other diseases, such as cancer, by detecting...
The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Title
The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
Author
Johnson, M. Brittany, Halman, Justin, Marriott, Ian, Afonin, Kirill A., Miller, Daniel K., Cooper, Joseph S., Khisamutdinov, Emil F.
Subjects--Topical
Immunology, Nucleic acids, Nanoparticles
Description
Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...
Low-dose metformin as a monotherapy does not reduce non-small-cell lung cancer tumor burden in mice
Title
Low-dose metformin as a monotherapy does not reduce non-small-cell lung cancer tumor burden in mice
Author
Marino, Joseph S., Stott Bond, Nicole L., Dréau, Didier, Marriott, Ian, Bennett, Jeanette M., Turner, Michael J., Arthur, Susan
Subjects--Topical
Lungs--Cancer, Musculoskeletal system
Description
Non-small-cell lung cancer (NSCLC) makes up 80–85% of lung cancer diagnoses. Lung cancer patients undergo surgical procedures, chemotherapy, and/or radiation. Chemotherapy and radiation can induce deleterious systemic side effects, particularly wi...
Low-dose metformin treatment reduces in vitro growth of the LL/2 non-small cell lung cancer cell line
Title
Low-dose metformin treatment reduces in vitro growth of the LL/2 non-small cell lung cancer cell line
Author
Marino, Joseph S., Dreau, Didier, Marriott, Ian, Bennett, Jeanette M.
Date Created
2022
Subjects--Topical
Cancer cells, Lungs--Cancer
Description
Lung cancer maintains a relatively small survival rate (~19%) over a 5-year period and up to 80-85% of all lung cancer diagnoses are Non-Small Cell Lung Cancer (NSCLC). To determine whether metformin reduces non-small cell lung cancer (NSCLC) LL/2...
Cytosolic DNA sensors and CNS responses to viral pathogens
Title
Cytosolic DNA sensors and CNS responses to viral pathogens
Author
Marriott, Ian, Jeffries, Austin
Subjects--Topical
DNA, Virus diseases
Description
Viral central nervous system (CNS) infections can lead to life threatening encephalitis and long-term neurological deficits in survivors. Resident CNS cell types, such as astrocytes and microglia, are known to produce key inflammatory and antivira...
Cytosolic DNA sensors and glial responses to endogenous DNA
Title
Cytosolic DNA sensors and glial responses to endogenous DNA
Author
Marriott, Ian, Suptela, Alexander J.
Date Created
2023
Subjects--Topical
Genomics, DNA
Description
Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses is a critical step in maintaining genomic integrity ...
Z-DNA binding protein 1 mediates necroptotic and apoptotic cell death pathways in murine astrocytes following herpes simplex virus-1 infection
Title
Z-DNA binding protein 1 mediates necroptotic and apoptotic cell death pathways in murine astrocytes following herpes simplex virus-1 infection
Author
Marriott, Ian, Jeffries, Austin M., Suptela, Alexander J.
Date Created
2022
Subjects--Topical
Herpes simplex virus, DNA
Description
The mechanisms by which glia respond to viral central nervous system (CNS) pathogens are now becoming apparent with the demonstration that microglia and astrocytes express an array of pattern recognition receptors that include intracellular RNA an...
Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles (NANPs)
Title
Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles (NANPs)
Author
Panigaj, Martin, Skelly, Elizabeth, Beasock, Damian, Marriott, Ian
Date Created
2023
Subjects--Topical
Immunology, Immune response--Regulation
Description
The immune system has evolved to defend organisms against exogenous threats such as viruses, bacteria, fungi, and parasites by distinguishing between self and non-self. In addition, it guards us against other diseases, such as cancer, by detecting...