Search results
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Title
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Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles
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Author
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Afonin, Kirill A., Marriott, Ian, Panigaj, Martin
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Date Created
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2023
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Subjects--Topical
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Nucleic acids, Chemistry
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Description
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The immune system has evolved to defend organisms against exogenous threats such as viruses, bacteria, fungi, and parasites by distinguishing between self and non-self. In addition, it guards us against other diseases, such as cancer, by detecting...
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Title
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The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
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Author
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Johnson, M. Brittany, Halman, Justin, Marriott, Ian, Afonin, Kirill A., Miller, Daniel K., Cooper, Joseph S., Khisamutdinov, Emil F.
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Subjects--Topical
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Immunology, Nucleic acids, Nanoparticles
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Description
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Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, th...
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Title
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Low-dose metformin as a monotherapy does not reduce non-small-cell lung cancer tumor burden in mice
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Author
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Marino, Joseph S., Stott Bond, Nicole L., Dréau, Didier, Marriott, Ian, Bennett, Jeanette M., Turner, Michael J., Arthur, Susan
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Subjects--Topical
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Lungs--Cancer, Musculoskeletal system
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Description
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Non-small-cell lung cancer (NSCLC) makes up 80–85% of lung cancer diagnoses. Lung cancer patients undergo surgical procedures, chemotherapy, and/or radiation. Chemotherapy and radiation can induce deleterious systemic side effects, particularly wi...
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Title
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Low-dose metformin treatment reduces in vitro growth of the LL/2 non-small cell lung cancer cell line
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Author
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Marino, Joseph S., Dreau, Didier, Marriott, Ian, Bennett, Jeanette M.
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Date Created
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2022
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Subjects--Topical
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Cancer cells, Lungs--Cancer
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Description
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Lung cancer maintains a relatively small survival rate (~19%) over a 5-year period and up to 80-85% of all lung cancer diagnoses are Non-Small Cell Lung Cancer (NSCLC). To determine whether metformin reduces non-small cell lung cancer (NSCLC) LL/2...
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Title
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Cytosolic DNA sensors and CNS responses to viral pathogens
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Author
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Marriott, Ian, Jeffries, Austin
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Subjects--Topical
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DNA, Virus diseases
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Description
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Viral central nervous system (CNS) infections can lead to life threatening encephalitis and long-term neurological deficits in survivors. Resident CNS cell types, such as astrocytes and microglia, are known to produce key inflammatory and antivira...
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Title
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Cytosolic DNA sensors and glial responses to endogenous DNA
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Author
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Marriott, Ian, Suptela, Alexander J.
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Date Created
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2023
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Subjects--Topical
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Genomics, DNA
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Description
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Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses is a critical step in maintaining genomic integrity ...
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Title
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Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles (NANPs)
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Author
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Panigaj, Martin, Skelly, Elizabeth, Beasock, Damian, Marriott, Ian
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Date Created
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2023
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Subjects--Topical
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Immunology, Immune response--Regulation
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Description
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The immune system has evolved to defend organisms against exogenous threats such as viruses, bacteria, fungi, and parasites by distinguishing between self and non-self. In addition, it guards us against other diseases, such as cancer, by detecting...