Search results
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Title
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Active Notch signaling is required for arm regeneration in a brittle star
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Author
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Janies, Daniel, Machado, Denis Jacob, Reid, Robert
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Date Created
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2020
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Subjects--Topical
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Genomics, Biology
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Description
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Cell signaling pathways play key roles in coordinating cellular events in development. The Notch signaling pathway is highly conserved across all multicellular animals and is known to coordinate a multitude of diverse cellular events, including pr...
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Title
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Calculating ensemble averaged descriptions of protein rigidity without sampling
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Author
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Jacobs, Donald J., Gonzalez, Luis C., Wang, Hui, Livesay, Dennis R.
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Date Created
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2012
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Subjects--Topical
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Biology, Proteins
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Description
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Previous works have demonstrated that protein rigidity is related to thermodynamic stability, especially under conditions that favor formation of native structure. Mechanical network rigidity properties of a single conformation are efficiently cal...
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Title
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High throughput nonparametric probability density estimation
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Author
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Jacobs, Donald J., Farmer, Jenny
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Date Created
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2018
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Subjects--Topical
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Statistics, Probabilities
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Description
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In high throughput applications, such as those found in bioinformatics and finance, it is important to determine accurate probability distribution functions despite only minimal information about data characteristics, and without using human subje...
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Title
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Patch dynamics modeling framework from pathogens' perspective : Unified and standardized approach for complicated epidemic systems
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Author
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Janies, Daniel, Chen, Shi, Lo, Eugenia, Dulin, Michael
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Date Created
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2020
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Subjects--Topical
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Communicable diseases, Biology
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Description
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Mathematical models are powerful tools to investigate, simulate, and evaluate potential interventions for infectious diseases dynamics. Much effort has focused on the Susceptible-Infected-Recovered (SIR)-type compartment models. These models consi...
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Title
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Phylogeny of echinoderm hemoglobins
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Author
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Janies, Daniel, Linchangco, Gregorio V., Jr.
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Date Created
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2015
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Subjects--Topical
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Genomics, Biology
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Description
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Background Recent genomic information has revealed that neuroglobin and cytoglobin are the two principal lineages of vertebrate hemoglobins, with the latter encompassing the familiar myoglobin and alpha-globin/beta-globin tetramer hemoglobin, and ...
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Title
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Redistribution of flexibility in stabilizing antibody fragment mutants follows Le Chatelier's principle
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Author
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Jacobs, Donald J., Li, Tong, Livesay, Dennis R.
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Date Created
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2014
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Subjects--Topical
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Immunoglobulins, Biology
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Description
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Le Chatelier's principle is the cornerstone of our understanding of chemical equilibria. When a system at equilibrium undergoes a change in concentration or thermodynamic state (i.e., temperature, pressure, etc.), La Chatelier's principle states t...
