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Understanding gene transcriptional regulation at single cell resolution
Title
Understanding gene transcriptional regulation at single cell resolution
Author
Xu, Chen
Date Created
2015
Subjects--Topical
Bioinformatics
Description
The recent advance of single-cell technologies has provided an unprecedented opportunity to bring new insights into many complex biological phenomena, such as the regulation of cell differentiation in a multi-cellular organism and cell-to-cell var...
UNDERSTANDING BIAS IN NEXT-GENERATION SEQUENCING TECHNOLOGIES AND ANALYSES
Title
UNDERSTANDING BIAS IN NEXT-GENERATION SEQUENCING TECHNOLOGIES AND ANALYSES
Author
Price, Adam
Date Created
2017
Subjects--Topical
Biology, Bioinformatics, Biophysics
Description
The problem of bias resulting from biological and technological sources is one that must be consistently reexamined alongside the development of new technologies and methods of analysis. This dissertation addresses the complexities of bias identif...
Evolution and dynamics of transcriptional regulation in bacteria
Title
Evolution and dynamics of transcriptional regulation in bacteria
Author
Li, Shan
Date Created
2013
Subjects--Topical
Computer science, Statistics, Bioinformatics
Description
Although transcription is one of the most important biological functions of cells, our understanding of its regulation is still limited. In this dissertation, we have studied the transcriptional regulation in prokaryotes in three aspects. First, w...