Advances in the cryopreservation of genetic material has revolutionized human reproductive medicine and animal conservation efforts. Despite many successes, oocytes have been more challenging to cryopreserve than sperm. Their large size makes it d...
Protein-based products have been developed to treat a range of conditions and are used in vaccines and assays. A challenge in the development of these products is maintaining the protein in the folded state during processing and storage. The most ...
Protein based drugs and therapeutics are an important treatment for many life-threatening diseases but they can also be extremely expensive. The unique 3-dimensional structure of a protein is responsible for its function but also contributes to it...
Spatial and temporal characteristics of molecular structure in ternary solutions of trehalose and choline dihydrogen phosphate (CDHP) are studied using molecular dynamics simulations at 300 K for a range of solute concentrations with a 2:1 stoichi...
The glassy or amorphous solid state of trehalose has been utilized in the food and pharmaceutical industry to immobilize and stabilize sensitive molecules and it is increasingly being explored for the preservation of biologics. Retention of the gl...
Cold storage can be challenging and expensive for the transportation and storage of biologics. We are developing a new processing technique, light-assisted drying (LAD), to prepare biologics for anhydrous storage in a trehalose amorphous solid mat...
