Search results | J. Murrey Atkins Library

Title: Regulation of Myosin IIIa Motor/Kinase Activity
Author: Moore, Judy
Date Created: 2009
Subjects--Topical: Biochemistry, Neurosciences, Cytology
Description: Myosin IIIa, a motor protein that localizes to actin-rich regions of photoreceptors and to stereocilia of inner ear hair cells, is associated with the hearing process in vertebrates and with phototransduction for invertebrates. It contains a large...

Title: Role of Intramolecular Electrostatic Interactions on the Kinetics of Human Cardiac Myosin β-Isoform
Author: Gargey, Akhil
Date Created: 2021
Subjects--Topical: Molecular biology, Biochemistry, Biophysics
Description: Human cardiac myosin has two isoforms, α and β, sharing significant sequence similarity, but different in kinetics. Small differences in the sequence are responsible for distinct local inter-residue interactions within α and β isoforms, leading to...

Title: Role of Nonmuscle Myosin II in Hepatic Stellate Cell Activation
Author: Moore, Cathy
Date Created: 2009
Subjects--Topical: Molecular biology
Description: The hepatic stellate cell (HSC) plays a pivotal role in the development of hepatic fibrosis. Regulation of liver microcirculation is a complex system where blood flow is under systemic and sinusoidal control. Upon a fibrogenic stimulus, quiescent ...

Title: Role of the DNA Sensors cGAS and ZBP1 in DNA Damage and Viral Infection
Author: Suptela, Alexander
Date Created: 2023
Subjects--Topical: Immunology, Molecular biology, Neurosciences
Description: Genomic instability is a key driving force for the development and progression of many neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of DNA damage responses (DDRs) is a critical step in maintaining genomic int...

Title: SNARE Protein Evolution and Expansion Drives Endosome Complexity
Author: Grissom, James
Date Created: 2023
Subjects--Topical: Cytology, Evolutionary developmental biology
Description: The budding yeast Saccharomyces cerevisiae is a powerful and well-studied model organism that is responsible for much of our understanding in the fields of endocytosis, the secretory pathway, and membrane trafficking. Traditionally, it was thought...

Title: SYMBIOSIS ACROSS DIET-INDUCED PHENOTYPES OF LARVAL SEA URCHINS
Author: Carrier, Tyler
Date Created: 2020
Subjects--Topical: Microbiology, Ecology, Aquatic sciences
Description: Larval sea urchins have served as a fundamental system for understanding development, phenotypic plasticity, and life-history evolution over much of the last century. In the recent decade, this understanding has begun to extend to the microbiota a...

Title: Screening of FDA-Approved Drug Library for Combinatorial Treatment of Pancreatic Ductal Adenocarcinoma Cells with Oncolytic Vesicular Stomatitis Virus
Author: Holbrook, Molly
Date Created: 2021
Subjects--Topical: Biology
Description: Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with poor prognosis and a dismal survival rate, expected to become the second leading cause of cancer-related deaths in the United States. Oncolytic virus (OV) is an anticancer ap...

Title: Sexual Dimorphism in Sepsis Susceptibility: Effects of Reproductive Hormones on Pattern Recognition Receptor Expression
Author: Rettew, Jennifer
Date Created: 2010
Subjects--Topical: Cytology
Description: Sex-based differences in innate immune responses to bacterial infection are evident in human patients and animal models of disease. Females are less susceptible to the development of bacterial infections and subsequent bacteremia and/or sepsis whi...

Title: Study of Enzymes Required for the Synthesis of the Enterobacterial Common Antigen in Vitro
Author: Oliverio, Cassidy
Date Created: 2021
Subjects--Topical: Biology
Description: In recent years, the Center for Disease Control (CDC) has highlighted many bacteria as being either serious or urgent threats in terms of antibiotic resistance such as Salmonella enterica, Klebsiella, and Shigella. These bacteria are all members o...

Title: Study of the Intracellular Protein Tau and its Relationship with Kunjin Virus and Neurodegenerative Diseases
Author: Lotz, Sarah
Date Created: 2022
Subjects--Topical: Neurosciences, Immunology, Virology
Description: Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, comprise a family of disorders characterized by progressive loss of nervous system function. Neuroinflammation is increasingly recogni...

Title: THE DEVELOPMENT OF NOVEL THERAPEUTICS IN PANCREATIC AND BREAST CANCERS: POTENTIAL ROLE OF MUC1
Author: Besmer, Dahlia
Date Created: 2013
Subjects--Topical: Biology
Description: Pancreatic ductal adenocarcinoma (PDA) is the 4th leading cause of cancer-related deaths in the US, and breast cancer (BC) contributes to ~40,000 deaths annually. The development of novel therapeutic agents for improving patient outcome is of para...

Title: THE ROLE OF MUC1 IN REGULATION AND PROGRESSION OF CANCER
Author: Sahraeimanouchehrabadi, Mahnaz
Date Created: 2011
Subjects--Topical: Immunology, Biology, Oncology
Description: MUC1 is a heavily glycosylated transmembrane glycoprotein which is overexpressed and aberrantly glycosylated in most human carcinomas. MUC1 contains a large tandem repeat, a short transmembrane, and a small cytoplasmic tail. Both tandem repeat and...

Title: THE ROLE OF OXYGEN ON THE IN VITRO AND IN SITU ECOPHYSIOLOGY OF MARINE VIBRIO SPECIES
Author: Phippen, Britney
Date Created: 2018
Subjects--Topical: Microbiology
Description: Hypoxia is an emerging concern in coastal ecosystems worldwide, and the number of areas experiencing hypoxia has increased exponentially in recent years. It is most prevalent in summer months when elevated temperatures lead to increased oxygen con...

Title: THE ROLE OF TRANSLESION SYNTHESIS POLYMERASES REV1 AND POL η IN DNA DAMAGE RESPONSE
Author: McLeod, Melissa
Date Created: 2016
Subjects--Topical: Molecular biology, Biology, Cytology
Description: Our cells endure continuous challenges from byproducts of endogenous metabolic processes as well as outside sources such as UV light and environmental polltants. The DNA Damage Response (DDR) helps organisms cope with damage and coordinate an appr...

Title: THE ROLE OF XRCC1 AND POLYMERASE BETA IN GENOME INTEGRITY IN XENOPUS EGG EXTRACTS
Author: Cupello, Steven
Date Created: 2019
Subjects--Topical: Molecular biology, Biology, Cytology
Description: Cells of organisms are constantly exposed to genomic insults such as oxidative stress from endogenous sources or environmental agents. Oxidative stress induces oxidative DNA damage such as apurinic/apyrimidinic (AP) sites, single-strand breaks (SS...

Title: TISSUE SPECIFIC RESPONSES OF THE ESTUARINE BIVALVE SPECIES CRASSOSTREA VIRGINICA AND GEUKENSIA DEMISSA TO HYPOXIA
Author: Khan, Bushra
Date Created: 2015
Subjects--Topical: Biology
Description: Aquatic ecosystems are exposed to multiple stressors simultaneously. Many estuarine sites which show diurnal dissolved oxygen (DO) and pH fluctuations are also exposed to metals which can be toxic to marine organisms. Bivalve mollusks serve as goo...

Title: TRANSCRIPTIONAL REGULATION OF GENES ASSOCIATED WITH DRUG RESISTANCE AND GROWTH OF PANCREATIC CANCER CELLS BY MUCIN 1
Author: Nath, Sritama
Date Created: 2013
Subjects--Topical: Molecular biology, Cytology, Oncology
Description: Pancreatic ductal adenocarcinoma (PDA) is the 4th leading cause of cancer-related deaths in the US. An understanding of the molecular pathogenesis of PDA is of utmost importance to be able to improve the current or design new targeted therapies fo...

Title: The Impact of Geographic Location on Larval Mortality and Analysis of Gene Expression in Nematostella vectensis Exposed to Acute and Chronic Thermal Stress
Author: Estvander, Sarah
Date Created: 2023
Subjects--Topical: Biology, Genetics
Description: Environmental temperature plays a critical role in the survival and geographic distribution of most organisms, as it can directly influence the rate of all biochemical and physiological reactions. Recent climate models show that seasonal variation...

Title: The Local Dynamics of Basement Membrane Breaching During Cancer Cell Invasion
Author: Nazari, Shayan
Date Created: 2022
Subjects--Topical: Biology
Description: Solid tumor metastasis is the leading cause of cancer-related mortality. Cancer invasion through the confining basement membrane (BM) is the initial step in tumor dissemination and metastasis, and it represents a key diagnostic feature of cancer. ...

Title: The Moon Jellyfish (Aurelia aurita): A Prospective Pelagic and Estuarine Bioindicator
Author: Lowder, Matthew
Date Created: 2016
Subjects--Topical: Biology, Environmental sciences, Toxicology
Description: Due in part to the complexity of scyphozoan life histories, slight changes in environmental factors can have an effect on fecundity, growth & development and population fluctuations. Anthropogenic activities have been suggested as a major cause of...