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Acquired chemoresistance can lead to increased resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
Title
Acquired chemoresistance can lead to increased resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
Author
Grdzelishvili, Valery, Goad, Dakota, Bressy, Christian, Holbrook, Molly
Subjects--Topical
Vesicular stomatitis, Cancer, Viruses
Description
Vesicular stomatitis virus (VSV) is a promising oncolytic virus (OV) against different malignancies, including pancreatic ductal adenocarcinoma (PDAC). Our previous studies have demonstrated that VSV-based OVs are effective against the majority of...
Cell cycle arrest in G2/M phase enhances replication of interferon-sensitive cytoplasmic RNA viruses via inhibition of antiviral gene expression
Title
Cell cycle arrest in G2/M phase enhances replication of interferon-sensitive cytoplasmic RNA viruses via inhibition of antiviral gene expression
Author
Grdzelishvili, Valery, Bressy, Christian, Droby, Gaith N., Maldonado, Bryant D., Steuerwald, Nury
Subjects--Topical
Cancer, Viruses
Description
Vesicular stomatitis virus (VSV) (a rhabdovirus) and its variant VSV-ΔM51 are widely used model systems to study mechanisms of virus-host interactions. Here, we investigated how the cell cycle affects replication of these viruses using an array of...
Combining oncolytic virotherapy with p53 tumor suppressor gene therapy
Title
Combining oncolytic virotherapy with p53 tumor suppressor gene therapy
Author
Grdzelishvili, Valery, Bressy, Christian, Hastie, Eric Lawrence
Subjects--Topical
Cancer, Gene therapy
Description
Oncolytic virus (OV) therapy utilizes replication-competent viruses to kill cancer cells, leaving non-malignant cells unharmed. With the first U.S. Food and Drug Administration-approved OV, dozens of clinical trials ongoing, and an abundance of tr...
Mesoporous silica nanoparticles loaded with cisplatin and phthalocyanine for combination chemotherapy and photodynamic therapy in vitro
Title
Mesoporous silica nanoparticles loaded with cisplatin and phthalocyanine for combination chemotherapy and photodynamic therapy in vitro
Author
Vivero-Escoto, Juan, Elnagheeb, Maram
Subjects--Topical
Chemotherapy, Cancer
Description
Mesoporous silica nanoparticles (MSNs) have been synthesized and loaded with both aluminum chloride phthalocyanine (AlClPc) and cisplatin as combinatorial therapeutics for treating cancer. The structural and photophysical properties of the MSN mat...
Novel biomarkers of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
Title
Novel biomarkers of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus
Author
Grdzelishvili, Valery, Hastie, Eric Lawrence, Cataldi, Marcela, Moerdyk-Schauwecker, Megan J., Felt, Sebastien A., Steuerwald, Nury
Subjects--Topical
Cancer, Viruses
Description
Vesicular stomatitis virus (VSV) based recombinant viruses (such as VSV-ΔM51) are effective oncolytic viruses (OVs) against a majority of pancreatic ductal adenocarcinoma (PDAC) cell lines. However, some PDAC cell lines are highly resistant to VSV...