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Intracellular lipid homeostasis and trafficking in autophagy

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Chi, R. J., Goyal, S., Robinson, M., & Segarra, V. A. (2019). Intracellular lipid homeostasis and trafficking in autophagy. Cell Growth. https://doi.org/doi:10.5772/intechopen.89683
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Description

In eukaryotes, lipids are not only an important constituent of the plasma membrane but are also used to generate specialized membrane-bound organelles, including temporary compartments with critical functions. As such, lipids play a key role in intracellular homeostasis—the ability of a cell to maintain stable internal conditions upon changes in its extracellular environment. Autophagy, one of the cellular processes through which eukaryotic cells strive for survival under stress, is heavily dependent on lipid and membrane trafficking through the de novo formation of autophagosomes—temporary, large, and double-bilayered organelles in which materials are encapsulated for recycling. This chapter discusses what we know about lipid homeostasis and trafficking during autophagy and autophagosome formation, and comments on future directions of the field.

Details
Title

Intracellular lipid homeostasis and trafficking in autophagy

Author(s)

Chi, Richard J.
Goyal, Shreya
Robinson, Meaghan
Segarra, Veronica A.

UNC Charlotte Affiliate Type

Faculty

Publisher

IntechOpen

Extent

1 online resource

Date Published

2019

Material Type

Book chapter

Genre

e-books

Resource Type

text

Abstract

In eukaryotes, lipids are not only an important constituent of the plasma membrane but are also used to generate specialized membrane-bound organelles, including temporary compartments with critical functions. As such, lipids play a key role in intracellular homeostasis—the ability of a cell to maintain stable internal conditions upon changes in its extracellular environment. Autophagy, one of the cellular processes through which eukaryotic cells strive for survival under stress, is heavily dependent on lipid and membrane trafficking through the de novo formation of autophagosomes—temporary, large, and double-bilayered organelles in which materials are encapsulated for recycling. This chapter discusses what we know about lipid homeostasis and trafficking during autophagy and autophagosome formation, and comments on future directions of the field.

Subjects--Topics

Lipids
Cells--Growth

Is Part Of

Cell growth

ISSN

978-1-78985-311-7

Language

English

Published Version (Please cite this version)

doi:10.5772/intechopen.89683

Publisher's Version

https://www.intechopen.com/chapters/69404

Permalink

http://hdl.handle.net/20.500.13093/work:196

Rights

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