There is a need to understand large and complex datasets to provide better situa- tional awareness in-order to make timely well-informed actionable decisions in critical environments. These types of environments include emergency evacuations for large buildings, indoor routing for buildings in emergency situations, large-scale critical infrastructure for disaster planning and first responders, LiDAR analysis for coastal planning in disaster situations, and social media data for health related analysis. I introduce novel work and applications in real-time interactive visual analytics in these domains. I also detail techniques, systems and tools across a range of disciplines from GPU computing for real-time analysis to machine learning for interactive analysis on mobile and web-based platforms.