The current literature on depression within HIV populations shows poorer outcomes for these individuals than those in the general population. To further these studies, I performed an analysis looking at the effects of formal and informal social support on an HIV population in the south. The data comes from a 2005 SAMHSA study of health outcomes of 320 HIV-positive individuals over a twelve month period. The individuals in this study were referred through an enhanced substance abuse program. Social support variables used included professional support, support from a partner, support from family and friends, and feelings of closeness to family and friends. Depression was measured in the study as the number of days depressed in the past 30 days. This variable was recoded into categories for the analysis in this paper. Regression analysis was used and findings showed variations in the effects of different forms of social support. Both formal and informal social support variables were found to have no significant effect on people living with HIV/AIDS. Race was found to be significant for levels of depression reported. Implications of this study could help to better future outcomes for individuals within this population.