Estimation Of Preference-Based Measures Of Health From Disease-Specific Clinical Outcome Measures For Total Hip And Knee Arthroplasty Patients

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Odum, S. (2013). Estimation Of Preference-Based Measures Of Health From Disease-Specific Clinical Outcome Measures For Total Hip And Knee Arthroplasty Patients. Unc Charlotte Electronic Theses And Dissertations.
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Abstract

Transfer to utility (TTU) or mapping methodology allows researchers to estimate a health utility from a disease-specific measure and calculate quality adjusted life years for economic evaluations. The purpose of this study was to develop regression algorithms to map five common disease specific TJA outcome measures to three preference-based health utility scores. An online survey was completed by 438 total hip arthroplasty (THA) patients and 550 total knee arthroplasty patients (TKA). THA patients completed the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC®), Harris Hip Score (HHS), and the Hip Disability and Osteoarthritis Outcomes Score (HOOS). Knee patients completed the WOMAC®, Knee Society Score (KSS), and Knee Disability and Osteoarthritis Outcomes Score (KOOS). All patients completed three preference based questionnaires, the SF-6D, EQ-5D and HUI-3, and responses were used to calculate health utilities. A total of 30 THA mapping models and 30 TKA mapping models were developed and validated. Forecast error measures including ME, MAE, RMSE were defined as our prediction performance criterion. For the THA models, the regression model with HOOS subscores most precisely estimated an EQ-5D health utility. The best performing TKA model mapped the KSS to the EQ-5D. Clinician-researchers can input their disease specific data into these models to estimate health utilities to consider the cost-effectiveness of osteoarthritis-related interventions relative to interventions for very different diseases and conditions.

Details
Author

Odum, Susan

Title

Estimation Of Preference-Based Measures Of Health From Disease-Specific Clinical Outcome Measures For Total Hip And Knee Arthroplasty Patients

Physical Description

1 online resource (111 pages) : PDF

Date

2013

Degree Granting Institution

University of North Carolina at Charlotte

Abstract

Transfer to utility (TTU) or mapping methodology allows researchers to estimate a health utility from a disease-specific measure and calculate quality adjusted life years for economic evaluations. The purpose of this study was to develop regression algorithms to map five common disease specific TJA outcome measures to three preference-based health utility scores. An online survey was completed by 438 total hip arthroplasty (THA) patients and 550 total knee arthroplasty patients (TKA). THA patients completed the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC®), Harris Hip Score (HHS), and the Hip Disability and Osteoarthritis Outcomes Score (HOOS). Knee patients completed the WOMAC®, Knee Society Score (KSS), and Knee Disability and Osteoarthritis Outcomes Score (KOOS). All patients completed three preference based questionnaires, the SF-6D, EQ-5D and HUI-3, and responses were used to calculate health utilities. A total of 30 THA mapping models and 30 TKA mapping models were developed and validated. Forecast error measures including ME, MAE, RMSE were defined as our prediction performance criterion. For the THA models, the regression model with HOOS subscores most precisely estimated an EQ-5D health utility. The best performing TKA model mapped the KSS to the EQ-5D. Clinician-researchers can input their disease specific data into these models to estimate health utilities to consider the cost-effectiveness of osteoarthritis-related interventions relative to interventions for very different diseases and conditions.

Genre

doctoral dissertations

Subjects--Topics

Economics
Medical sciences

Degree

Ph.D.

Keywords

Cost-Effectiveness
Cost Utility Analysis
Health Utility
Quality Adjusted Life Years
Total Hip Arthroplasty
Total Knee Arthroplasty

Subject Area

Health Services Research

Advisor(s)

Troyer, Jennifer

Committee Members

Brandon, William
Dmochowski, Jacek
Laditka, Sarah
McGregor, Rob Roy

Degree Note

Thesis (Ph.D.)--University of North Carolina at Charlotte, 2013.

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This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). For additional information, see http://rightsstatements.org/page/InC/1.0/.

Rights Holder Information

Copyright is held by the author unless otherwise indicated.

Identifier

Odum_uncc_0694D_10477

Permalink

http://hdl.handle.net/20.500.13093/etd:247