Influence of Functional Groups on the Photodynamic Therapy and Internalization of Porphyrin Modified Polyhedral Oligomeric Silsesquioxane (POSS) Molecules in Mammalian Cells

Search for this publication on Google Scholar
Johnston, A. (2020). Influence of Functional Groups on the Photodynamic Therapy and Internalization of Porphyrin Modified Polyhedral Oligomeric Silsesquioxane (POSS) Molecules in Mammalian Cells. Unc Charlotte Electronic Theses And Dissertations.
Download PDF

Analytics

62 views ◎
33 downloads ⇓


Abstract

Polyhedral Oligomeric Silsesquioxane (POSS) molecules are highly ordered organic- inorganic hybrid materials with a cage like core of alternating silicon and oxygen atoms surrounded by eight pedant organic residues. These compounds are well-defined, 3D building blocks that can form hybrid materials with precise control of the nanostructure and properties. POSS molecules are used in a wide variety of medical fields, for example, tissue engineering and drug delivery, or for the oligomerization of bioactive ligands, among them peptides and carbohydrates. They are considered non-toxic and hydrolytic degradation of the inorganic core under physiological conditions has been thoroughly investigated. In this work, we have taken advantage of the chemical and structural properties of POSS to functionalize this material with porphyrin. Moreover, the corner groups have been functionalized with either isobutyl or phenyl groups. We hypothesize that the differences in surface functionalization will have a major impact on the internalization and phototoxicity and of POSS-Porphyrin against mammalian cancer cells. Further studies will expand the scope of this investigation with drug-conjugated POSS molecules and target-specific systems.

Details
Author

Johnston, Alexis

Title

Influence of Functional Groups on the Photodynamic Therapy and Internalization of Porphyrin Modified Polyhedral Oligomeric Silsesquioxane (POSS) Molecules in Mammalian Cells

Physical Description

1 online resource (77 pages) : PDF

Date

2020

Degree Granting Institution

University of North Carolina at Charlotte

Abstract

Polyhedral Oligomeric Silsesquioxane (POSS) molecules are highly ordered organic- inorganic hybrid materials with a cage like core of alternating silicon and oxygen atoms surrounded by eight pedant organic residues. These compounds are well-defined, 3D building blocks that can form hybrid materials with precise control of the nanostructure and properties. POSS molecules are used in a wide variety of medical fields, for example, tissue engineering and drug delivery, or for the oligomerization of bioactive ligands, among them peptides and carbohydrates. They are considered non-toxic and hydrolytic degradation of the inorganic core under physiological conditions has been thoroughly investigated. In this work, we have taken advantage of the chemical and structural properties of POSS to functionalize this material with porphyrin. Moreover, the corner groups have been functionalized with either isobutyl or phenyl groups. We hypothesize that the differences in surface functionalization will have a major impact on the internalization and phototoxicity and of POSS-Porphyrin against mammalian cancer cells. Further studies will expand the scope of this investigation with drug-conjugated POSS molecules and target-specific systems.

Genre

masters theses

Subjects--Topics

Chemistry
Chemistry, Inorganic
Chemistry, Organic

Degree

M.S.

Subject Area

Chemistry

Advisor(s)

Vivero-Escoto, Juan

Committee Members

Fried, Nathaniel
Schmedake, Tom
Troutman, Jerry

Degree Note

Thesis (M.S.)--University of North Carolina at Charlotte, 2020.

Rights Statement

This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). For additional information, see http://rightsstatements.org/page/InC/1.0/.

Rights Holder Information

Copyright is held by the author unless otherwise indicated.

Identifier

Johnston_uncc_0694N_12544

Permalink

http://hdl.handle.net/20.500.13093/etd:1939