SYNTHESIS OF PORPHYRIN-BASED POLYHEDRAL OLIGOMERIC SILSESQUIOXANE MOLECULES FOR IMPROVED PHOTODYNAMIC THERAPY OF CANCER CELLS

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Siano, P. (2020). SYNTHESIS OF PORPHYRIN-BASED POLYHEDRAL OLIGOMERIC SILSESQUIOXANE MOLECULES FOR IMPROVED PHOTODYNAMIC THERAPY OF CANCER CELLS. Unc Charlotte Electronic Theses And Dissertations.
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Abstract

Polyhedral Oligomeric Silsesquioxane (POSS) materials are a class of nanostructured compounds based on Si-O linkages forming a cage with a silicon atom at each vertex, where substituents are bound tetrahedrally determining the physical and chemical properties of the cage. The vast variety of functional groups that can be added to the cage allows for this class of nanocomposites to be used in a variety of applications such as design of novel materials, bioimaging and drug delivery to name a few. Photosensitizers like porphyrins used in light-activated therapies are hydrophobic molecules leading to self-aggregation in aqueous media, causing decreased bioavailability for biomedical applications. We hypothesize that by using the multifunctionality of POSS platform, we can selectively introduce photosensitizer(s), with targeting and hydrophilic groups for tuning the final properties of the POSS derivatives. The aims for my project are: 1) synthesize porphyrin-based octaaminopropyl-POSS and the trimethylammonium version, and 2) fabricate porphyrin-based bifunctional POSS system containing a targeting group. These novel molecules will be used for the selective elimination of cancer cells.

Details
Author

Siano, Paolo

Title

SYNTHESIS OF PORPHYRIN-BASED POLYHEDRAL OLIGOMERIC SILSESQUIOXANE MOLECULES FOR IMPROVED PHOTODYNAMIC THERAPY OF CANCER CELLS

Physical Description

1 online resource (121 pages) : PDF

Date

2020

Degree Granting Institution

University of North Carolina at Charlotte

Abstract

Polyhedral Oligomeric Silsesquioxane (POSS) materials are a class of nanostructured compounds based on Si-O linkages forming a cage with a silicon atom at each vertex, where substituents are bound tetrahedrally determining the physical and chemical properties of the cage. The vast variety of functional groups that can be added to the cage allows for this class of nanocomposites to be used in a variety of applications such as design of novel materials, bioimaging and drug delivery to name a few. Photosensitizers like porphyrins used in light-activated therapies are hydrophobic molecules leading to self-aggregation in aqueous media, causing decreased bioavailability for biomedical applications. We hypothesize that by using the multifunctionality of POSS platform, we can selectively introduce photosensitizer(s), with targeting and hydrophilic groups for tuning the final properties of the POSS derivatives. The aims for my project are: 1) synthesize porphyrin-based octaaminopropyl-POSS and the trimethylammonium version, and 2) fabricate porphyrin-based bifunctional POSS system containing a targeting group. These novel molecules will be used for the selective elimination of cancer cells.

Genre

masters theses

Subjects--Topics

Chemistry

Degree

M.S.

Keywords

Bioavailability
Drug Delivery
PDT
Photosensitizer
Porphyrin
POSS

Subject Area

Chemistry

Advisor(s)

Vivero-Escoto, Juan

Committee Members

Indrasekara, Swarnapali
Munir, Mariya
Walter, Michael

Degree Note

Thesis (M.S.)--University of North Carolina at Charlotte, 2020.

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Rights Holder Information

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Identifier

Siano_uncc_0694N_12493

Permalink

http://hdl.handle.net/20.500.13093/etd:1833