DESIGN, SYNTHESIS AND CHARACTERIZATION OF MULTIFUNCTIONAL REDOX-RESPONSIVE PORPHYRIN-BASED POLYSILSESQUIOXANE NANOMATERIALS FOR PHOTODYNAMIC THERAPY

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Vega, D. (2015). DESIGN, SYNTHESIS AND CHARACTERIZATION OF MULTIFUNCTIONAL REDOX-RESPONSIVE PORPHYRIN-BASED POLYSILSESQUIOXANE NANOMATERIALS FOR PHOTODYNAMIC THERAPY. Unc Charlotte Electronic Theses And Dissertations.
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Abstract

Photodynamic Therapy (PDT) is a minimally invasive clinically approved cancertreatment that was first applied in the early 20th century. PDT is an attractive alternative when compared to chemotherapy and radiation therapy due to the lack of harmful side effects associated with these modalities. This treatment is based on the therapeutic effect of reactive oxygen species (ROS) generated after irradiation to activate a light-sensitive molecule called a photosensitizer (PS). Despite the advantages of PDT for cancer treatment, there are some drawbacks with current PS molecules such as inadequate energy absorption, poor solubility in water, and the inability to target tumor cells. Nanoparticles (NPs) are promising materials to be utilized for PDT. NPs have the ability to be target-specific towards tumor tissue, biocompatible and biodegradable. However, current nanocarriers do not show the optimal PDT response due to self-quenching and low singlet oxygen generation. The main target of this project is to develop stimuli-responsive hybrid nanoparticles based on tetrakis(carboxy)phenyl porphyrin (TCPP) derivatives with an enhanced ability to carry and deliver large amount of PSs to improve the PDT effect. This platform will be further functionalized with polyethylene glycol (PEG) and a targeting ligand, Folic acid (FA) to improve its biocompatibility and target specificity.

Details
Author

Vega, Daniel

Title

DESIGN, SYNTHESIS AND CHARACTERIZATION OF MULTIFUNCTIONAL REDOX-RESPONSIVE PORPHYRIN-BASED POLYSILSESQUIOXANE NANOMATERIALS FOR PHOTODYNAMIC THERAPY

Physical Description

1 online resource (84 pages) : PDF

Date

2015

Degree Granting Institution

University of North Carolina at Charlotte

Abstract

Photodynamic Therapy (PDT) is a minimally invasive clinically approved cancertreatment that was first applied in the early 20th century. PDT is an attractive alternative when compared to chemotherapy and radiation therapy due to the lack of harmful side effects associated with these modalities. This treatment is based on the therapeutic effect of reactive oxygen species (ROS) generated after irradiation to activate a light-sensitive molecule called a photosensitizer (PS). Despite the advantages of PDT for cancer treatment, there are some drawbacks with current PS molecules such as inadequate energy absorption, poor solubility in water, and the inability to target tumor cells. Nanoparticles (NPs) are promising materials to be utilized for PDT. NPs have the ability to be target-specific towards tumor tissue, biocompatible and biodegradable. However, current nanocarriers do not show the optimal PDT response due to self-quenching and low singlet oxygen generation. The main target of this project is to develop stimuli-responsive hybrid nanoparticles based on tetrakis(carboxy)phenyl porphyrin (TCPP) derivatives with an enhanced ability to carry and deliver large amount of PSs to improve the PDT effect. This platform will be further functionalized with polyethylene glycol (PEG) and a targeting ligand, Folic acid (FA) to improve its biocompatibility and target specificity.

Genre

masters theses

Subjects--Topics

Materials science
Chemistry
Nanotechnology

Degree

M.S.

Keywords

Nanomaterials
Photodynamic Therapy
Polysilsesquioxane
Redox-Responsive

Subject Area

Chemistry

Advisor(s)

Vivero-Escoto, Juan

Committee Members

Ogle, Craig
Walter, Michael
Fried, Nathaniel

Degree Note

Thesis (M.S.)--University of North Carolina at Charlotte, 2015.

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Rights Holder Information

Copyright is held by the author unless otherwise indicated.

Identifier

Vega_uncc_0694N_10942

Permalink

http://hdl.handle.net/20.500.13093/etd:151